Detalhe da pesquisa
1.
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.
Immunity
; 54(12): 2877-2892.e7, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34852217
2.
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
; 53(6): 1281-1295.e5, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33296685
3.
IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.
Proc Natl Acad Sci U S A
; 121(13): e2319856121, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38513098
4.
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.
Mol Ther
; 32(5): 1344-1358, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38454606
5.
Nucleoside-Modified mRNA Vaccines Protect IFNAR-/- Mice against Crimean-Congo Hemorrhagic Fever Virus Infection.
J Virol
; 96(3): e0156821, 2022 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34817199
6.
Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Mol Ther
; 30(9): 2909-2922, 2022 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581938
7.
Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection.
Mol Ther
; 29(9): 2769-2781, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33992803
8.
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice.
Mol Ther
; 28(7): 1569-1584, 2020 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32359470
9.
Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents.
J Liposome Res
; 26(2): 96-102, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25856305
10.
The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes.
J Immunol
; 184(11): 6092-102, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20427776
11.
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.
Mol Ther
; 19(12): 2186-200, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21971424
12.
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.
Angew Chem Int Ed Engl
; 51(34): 8529-33, 2012 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22782619
13.
Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses.
Nat Commun
; 13(1): 4677, 2022 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35945226
14.
CAR T cells produced in vivo to treat cardiac injury.
Science
; 375(6576): 91-96, 2022 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34990237
15.
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.
Cell Rep
; 38(11): 110514, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35294883
16.
Preclinical Assessment of a Gene-Editing Approach in a Mouse Model of Mitochondrial Neurogastrointestinal Encephalomyopathy.
Hum Gene Ther
; 32(19-20): 1210-1223, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34498979
17.
Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles.
Int Immunol
; 21(7): 757-67, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19502586
18.
The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine.
J Gene Med
; 11(1): 14-25, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19003796
19.
Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles.
Int Immunopharmacol
; 7(8): 1064-75, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17570323
20.
Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy.
Adv Drug Deliv Rev
; 61(3): 233-42, 2009 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19232375